Atletico Nacional and Cucuta Deportivo, two of Colombia's representatives in the 2008 Copa Libertadores, both lost their respective matches of the first round of the Colombian championship.

Five teams won on the road in the first round of the Colombian championship, with the most important victory being that of Independiente, 1-0 over reigning champions Atletico Nacional de Medellin, with a strike from Leider Preciado.

While, Envigado continued from where they left off in the Second Division, with a 2-0 victory over Deportivo Pereira, with goals from Giovanny Moreno and Neider Morantes.

In Bogota, Deportivo Independiente Medellin beat Millonarios 2-1 with goals from Danilson Cordoba and Jaime Castrillon, while Jonathan Estrada scored for Millonarios.

In the clasico de los santanderes, Atletico Bucaramanga edged Cucuta Deportivo 1-0, with a strike from Alex Sinisterra.

While, Boyaca Chico defeated Deportivo Pasto 1-0, with a strike from Ferley Villamil.

The only teams who won at home were Deportes Tolima, who beat Deportivo Cali 2-0, and Junior de Barranquilla, who defeated Once Caldas 2-1.